Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

A case of hypoglycemic coma with good outcome despite sustained unconsciousness and widespread leukoencephalopathy

Satoshi Yokoi, M.D.1)3), Keizo Yasui, M.D.1), Yasuhiro Hasegawa, M.D.1), Takatoshi Kasai, M.D.2), Akemi Inagaki, M.D.2) and Gen Sobue, M.D.3)

1)Department of Neurology, Nagoya Daini Red Cross Hospital
2)Department of Diabetology and Endocrinology, Nagoya Daini Red Cross Hospital
3)Department of Neurology, Nagoya University, Graduate School of Medicine

We described a 28-year-old woman with insulinoma-induced hypoglycemic coma. Her initial diffusion-weighted MRI revealed diffuse hyperintense lesions involving bilateral hemispheric white matter. She did not respond to the initial treatment with glucose. However, after surgical removal of insulinoma, she began to recover gradually, and 1 year later, returned to her previous work. In general, the outcome of hypoglycemic coma with widespread leukoencephalopathy on MRI is thought to be poor. However, we should be aware that some of such cases could recover in the long term.
Full Text of this Article in Japanese PDF (2317K)

(CLINICA NEUROL, 53: 724|727, 2013)
key words: hypoglycemic coma, insulinoma, leukoencephalopathy, steroid

(Received: 12-Dec-12)