Rinsho Shinkeigaku (Clinical Neurology)

Symposium 4

Amyotrophic lateral sclerosis in totally locked-in state

Kiyomitsu Oyanagi, M.D., Ph.D.1), Yoko Mochizuki, M.D., Ph.D.2)3), Yuki Nakayama, R.N., Ph.D.4), Kentaro Hayashi, M.D.5), Toshio Shimizu, M.D.5), Masahiro Nagao, M.D.5), Tomoyo Hashimoto, M.D., Ph.D.1)6), Mineo Yamazaki, M.D., Ph.D.7), Shiro Matsubara, M.D., Ph.D.5) and Takashi Komori, M.D., Ph.D.2)

1)Department of Brain Disease Research, Shinshu University School of Medicine
2)Department of Pathology, Tokyo Metropolitan Neurological Hospital
3)Department of Neurology, Tokyo Metropolitan Kita Medical and Rehabilitation Center for the Disabled
4)Laboratory of Nursing Research for Intractable Disease, Tokyo Metropolitan Institute of Medical Science
5)Department of Neurology, Tokyo Metropolitan Neurological Hospital
6)Department of Neurology, University of Occupational and Environmental Health
7)Department of Neurology, Nippon Medical University

Seven autopsy patients with amyotrophic lateral sclerosis (ALS) in totally locked-in state (TLS) were examined neuropathologically. The patients were composed of 4 males and 3 females, and 3 with familial, 1 sporadic but with mutation in SOD1 gene, and 3 sporadic patients with unremarkable gene mutation. The brains weighed 715, 783, 1,019, 1,050, 1,170, 1,190 or 1,233 g. The tegmentum of the brain stem was markedly degenerated in every patient, and the tracts relating to the somatic sensory and auditory were involved in the lesions.
Full Text of this Article in Japanese PDF (1460K)

(CLINICA NEUROL, 53: 1399|1401, 2013)
key words: amyotrophic lateral sclerosis (ALS), totally locked-in state (TLS), brain machine interface

(Received: 1-Jun-13)