Rinsho Shinkeigaku (Clinical Neurology)

Symposium 4

The cardiac reserve in Parkinson's disease and exercise therapy

Masaaki Hirayama, M.D.1)2), Tomohiko Nakamura, M.D.2) and Gen Sobue, M.D.2)

1)Department of Medical Laboratory Sciences, Nagoya University Graduate School of Medicine
2)Department of Neurology, Nagoya University Graduate School of Medicine

The clinical feature of Parkinson's disease (PD) is not based on the identification of the extrapyramidal symptom such as bradykinesia, restinbg tremor, rigidity, but also other non-motor symptom (REM sleep disorder, autonomic dysfunction, hyposmia etc). According to the cardio-sympathetic dysfunction, it is well known abnormal MIBG and orthostatic hypotension finding was seen in early disease stage. Furthermore denervation supersensitivity using β1 stimulant correlates the severity of MIBG image, so that this abnormal cardiac function induces inadequate cardiac capacity for exercise. Inadequate cardiac capacity makes easy fatigability, which correlates the abnormal MIBG image and cardio-sympathetic damage. So it is difficult to prescribe a specific exercise program to meet individual PD patients needs. Music therapy and trunk exercise(for example Tai-Chi exercise) are better suited for PD patients.
Full Text of this Article in Japanese PDF (734K)

(CLINICA NEUROL, 53: 1376|1378, 2013)
key words: cardiac reserve, MIBG, fatigue, cardiac sympathetic, exercise therapy

(Received: 1-Jun-13)