Rinsho Shinkeigaku (Clinical Neurology)

Symposium 3

Olfactory mucosa autograft for chronic complete spinal cord injury

Koichi Iwatsuki, M.D., Ph.D.1)

1)Neurosurgery, Osaka University Medical School

The efficacy of olfactory mucosa autograft (OMA) for chronic spinal cord injury has been reported. New activity in response to voluntary effort has been documented by electromyography (EMG), but the emergence of motor evoked potential (MEP) reflecting electrophysiological conductivity in the central nervous system, including the corticospinal pathway after OMA has not been clarified. We report the emergence of MEPs after OMA. Methods: Four patients, 3 men and 1 woman, were enrolled. The mean age of the cases was 30.3 ± 9.5 years (range, 19 to 40 years). All 4 cases were American Spinal Injury Association (ASISA) grade A. The mean duration from injury to OMA was 95. 8 ± 68.2 months (range, 17 to 300 months). Samples of olfactory mucosa were removed, cut into smaller pieces, and grafted into the sites of spinal cord lesions after laminectomy. Improvements in ASIA grade, variations in ASIA scores, EMG, SSEP, and improved urological function were evaluated as efficacy indicators. Results: There were no serious adverse events in this series. In 2 of the 4 cases, an improvement in motor function below the level of injury was recognized. The emergence of MEP was recognized in the latter case at 96 weeks after surgery.
Full Text of this Article in Japanese PDF (605K)

(CLINICA NEUROL, 53: 1180|1182, 2013)
key words: olfactory mucosa, spinal cord injury, regenerative medicine

(Received: 31-May-13)