Rinsho Shinkeigaku (Clinical Neurology)

Symposium 1

Drugs for migraine prophylaxis

Takao Takeshima, M.D., Ph.D.

Department of Neurology, Headache Center, Tominaga Hospital

Migraine is a prevalent and disabling neurologic disorder. The aims of migraine management are lifting the burden of migraine and improvement of quality of life (QOL) of the sufferers. Chronification of episodic migraine would introduce refractory chronic migraine or medication overuse headache. The prevention of chronification of migraine is one of the major roles of prophylactic medication. There are some classes of prophylactic drugs against migraine headache. The calcium blocker (lomeridine, verapamil), anti-epileptic drugs (valproate), beta-blockers (propranorol), and anti-depressant (amytriptyline) have high quality evidence in migraine prophylaxis. Migraine has varied cormorbid disorders, such as hypertension, cardiac diseases, cerebrovascular diseases, psychiatric disorders, epilepsy, and allergic disorders. Upon choosing preventive drug, neurologists should consider the comorbid disorders. Recent studies revealed possible association of migraine and cerebrovascular diseases, especially in migraine with aura and in young women. Not only headache expert but every neurologist should have broad knowledge concerning migraine management.
Full Text of this Article in Japanese PDF (237K)

(CLINICA NEUROL, 52: 973|975, 2012)
key words: valproate, beta-blocker, Ca blocker, cerebral infarction, comorbid disorder

(Received: 23-May-12)