Rinsho Shinkeigaku (Clinical Neurology)


Future neuroprotective strategies in the post-thrombolysis era -Neurovascular unit protection and vascular endothelial protection-

Tatsushi Kamiya, M.D., Ph.D.1) and Koji Abe, M.D., Ph.D.2)

1)Department of Neurology, Kamiya Iin
2)Department of Neurology, Division of Neuroscience, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

From an appearance of recombinant tissue plasminogen activator (rt-PA) in the clinical therapy on 2005 in Japan, the therapeutic strategy of ischemic stroke therapy is now changing dramatically. Many experimental data from animal stroke and clinical trials of neuroprotective agents failed to clinical useful therapeutic strategy. A free radical scavenger, edaravone is the first clinical drug for neuroprotection in the world which has been used in almost all ischemic stroke patients in Japan from 2001. Now, it is especially useful in thrombolytic therapy with rt- PA, whereas we still need the newly more effective neuroprotective drugs which can be applied to many ischemic stroke patients. Therefore, we review and describe the future neuroprotective strategies in the post-thrombolysis era.
Full Text of this Article in Japanese PDF (1359K)

(CLINICA NEUROL, 51: 305|315, 2011)
key words: acute ischemic stroke, neuroprotection, thrombolysis, ischemic cell death, therapeutic time window

(Received: 13-Jan-11)