Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

An experience of administration of modafinil for excessive daytime sleepiness in a patient with myotonic dystorophy

Mikiya Suzuki, M.D.1)2), Yasushi Oya, M.D.1) and Mitsuru Kawai, M.D.1)2)

1)Department of Neurology, National Center Hospital of Neurology and Psychiatry
2)Department of Neurology, National Higashisaitama Hospital

We report the beneficial and adverse effects of modafinil for daytime sleepiness in a 62-year-old female patient with myotonic dystrophy. Although it was effective for excessive daytime sleepiness, orolingual dyskinesia appeared the day following administration of modafinil (100 mg/day), and dyskinesia disturbed her daily life including dental treatment. When modafinil was stopped, dyskinesia was improved. However, excessive daytime sleepiness deteriorated gradually; re-treatment with smaller dosage (50 mg every other day) resulted in partial improvement but aggravation of both dyskinesia and diabetes mellitus. Modafinil should be administered carefully when the patient is older or has complications such as glucose intolerance.
Full Text of this Article in Japanese PDF (276K)

(CLINICA NEUROL, 50: 578|580, 2010)
key words: myotonic dystrophy, excessive daytime sleepiness, modafinil, dyskinesia, diabetes

(Received: 7-Dec-09)