Rinsho Shinkeigaku (Clinical Neurology)

The 50th Annual Meeting of the Japanese Society of Neurology

Mechanism underlying thrombus formation in cerebral infarction

Kazuo Kitagawa, M.D. and Saburo Sakoda, M.D.

Department of Neurology, Osaka University Graduate School of Medicine

For thrombus formation, three important factors, blood flow, blood component and blood vessels, have been recognized as Virchow's triad. In cardiogenic embolism with atrial fibrillation, stagnation of blood in the left atrium causes fibrin-rich thrombus. Anticoagulation is the only effective drug for prevention of this type of thrombus. In atherothrombotic and lacunar infarction, injury of endothelium and arterial vessels and platelet play a crucial role of formation of platelet-rich thrombus. Antiplatelet drugs such as aspirin, clopidogrel and cilostazole are effective for prevention of arterial thrombus and stroke recurrence, but other drugs such as statin for plaque stabilization and improvement of endothelial function could be used to reduce the recurrence of ischemic stroke.
Full Text of this Article in Japanese PDF (382K)

(CLINICA NEUROL, 49: 798|800, 2009)
key words: anticoagulation, anti-platelet drug, plaque vulnerability, inflammation, statin

(Received: 21-May-09)