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• Vol.49 No.11
• CLINICA NEUROL, 49: 753−755, 2009
• Vol.49 No.11 contents

The 50th Annual Meeting of the Japanese Society of Neurology

The studies of gene therapy for Parkinson's disease

Hideki Mochizuki, M.D.

Department of Neurology, Kitasato University

Currently, four Phase I clinical trials are underway utilizing recombinant adeno-associated viral (rAAV) vectors for the treatment of Parkinson's disease. The vehicle used mainly for gene delivery to the human brain is rAAV vector, which is non-pathogenic and non-self-amplifying. At present, the gene therapy approach is not the best way for the treatment of PD patients, but we believe that the further progress is anticipated toward making this strategy a therapeutic option for PD in the future. This article will review currently ongoing clinical trials of PD gene therapy and then introduce our studies about the gene therapy for PD.
Full Text of this Article in Japanese PDF (463K)

(CLINICA NEUROL, 49: 753−755, 2009)
key words: Gene therapy, Parkinson's disease, AAV vector, parkin

(Received: 20-May-09)