臨床神経学

<シンポジウム(4)―16―5>パーキンソン病(PD)の自律神経障害〜全身とのクロストーク

PD/DLBの抗コリン薬と認知機能

榊原 隆次1)

1)東邦大学医療センター佐倉病院神経内科〔〒285-0814 千葉県佐倉市下志津564-1〕

Overactive bladder (OAB) is a common autonomic disorder due mostly to lesions in the micturitioninhibiting area (D1 dopaminergic pathway in the basal ganglia) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). anticholinergic drugs are the mainstay in the treatment of OAB. However, since 1997, anticholinergic adverse events on the cognitive function have been recognized. Drugs with less lipophilic, less permeable through the blood-brain barrier are the choice in the treatment of OAB in elderly neurologic patients.
Full Text of this Article in Japanese PDF (1198K)

(臨床神経, 53:1389−1392, 2013)
key words:認知機能,抗コリン薬,過活動膀胱,パーキンソン病,レヴィー小体型認知症

(受付日:2013年6月1日)