臨床神経学

<シンポジウム(3)―16―2>神経学と精神医学の境界を再度越える

精神疾患の脳画像研究

鬼塚 俊明

九州大学病院精神科神経科〔〒812―8582 福岡市東区馬出3―1―1〕

Recently, neuroscience approach has revealed new findings in the mental disorder of schizophrenia, now clearly established as a brain disease, and affecting 1% of the world population. Its onset from 18-25 years cripples people in the most productive period of their lives with positive symptoms (thought disorder, delusions, hallucinations) and negative symptoms (poor social relationships and self care). In this article, the author has overviewed magnetic resonance imaging (MRI) findings in patients with schizophrenia. Recent MRI studies show it is characterized in MRI by loss of brain gray matter (neuropil, not cells), some of which occurs before full symptom onset and some of which progresses in the 1-2 years after onset. This is most prominent in some neocortical regions and is associated with worsening of symptoms. To understand the pathophysiologic basis, neuroscience efforts and collaborations between neurologists and psychiatrists will be important.
Full Text of this Article in Japanese PDF (191K)

(臨床神経, 52:1376−1378, 2012)
key words:統合失調症,MRI,進行性変化

(受付日:2012年5月25日)