臨床神経学

<シンポジウム(2)―14―3>パーキンソン病の病態生理

パーキンソン病の可塑性の異常・薬物効果

榎本 博之, 宇川 義一

福島県立医科大学神経内科〔〒960―1295 福島県福島市光が丘1番地〕

The repetitive transcranial magnetic stimulation (rTMS) has been studied as a method to induce plasticity changes in the human brain. And rTMS is expected as a therapeutic tool for Parkinson's disease, depression, intractable pain and others. We reported a new rTMS protocol, quadripulse stimulation (QPS), is more effective. QPS consists of repeated trains of four monophasic TMS pulses separated by inter-stimulus intervals of 5 ms (QPS-5) and 50 ms (QPS-50), inducing bidirectional motor cortical plasticity in an ISI dependent. QPS-5 leads to the potentiation effect. QPS-50 leads to a depression effect. We investigated the changes of plasticity induced by QPS in patients with Parkinson's disease and the healthy volunteer with oral administration of levodopa. In patients with Parkinson's disease the effect of QPS-5 and QPS-50 was attenuated at Off period. However, when the On period it was recovered. In healthy subjects, effect of QPS was enhanced by levodopa, both QPS-5 and QPS-50.
Full Text of this Article in Japanese PDF (170K)

(臨床神経, 52:1204−1206, 2012)
key words:経頭蓋磁気刺激法,単相性4連発磁気刺激法,パーキンソン病,可塑性,レボドパ

(受付日:2012年5月24日)