＜シンポジウム（1）―10―4＞片頭痛の病態研究Update
片頭痛慢性化のメカニズム
柴田 護
慶應義塾大学医学部神経内科〔〒160―8582 東京都新宿区信濃町35〕
Chronification of migraine occurs in approximately 3% of entire cases annually. Some risk factors, like obesity and affective disorder, exacerbate the migraine disease conditions. The incidence of migraine chronification is dependent on the baseline frequency of migraine attacks. Functional MRI data support that dysfunction of the descending anti-nociceptive systems plays an important role in the development of migraine chronification. Moreover, several studies employing voxel-based morphometry have revealed morphological alterations of gray matter density in various brain regions, some of which are irrelevant to the sensory or limbic systems. It remains to be determined whether such organic changes are either causative of or attributable to migraine chronification. A preclinical study showed that cortical spreading depression can activate matrix metalloproteinase-9, potentially leading to disruption of blood-brain barrier and subsequent parenchymal damage. We demonstrated that TRPV1 (transient receptor potential vanilloid subfamily, member 1) stimulation in the trigeminal nociceptors induces morphological changes of microglia and astrocytes in the trigeminal nucleus caudalis. Recently, botulinum neurotoxin type-A (BoNT-A) has been approved for patients with chronic migraine. The primary action of BoNT-A is inhibition of regulated exocytosis at the peripheral nerve terminals, raising the possibility that certain peripheral factors are implicated in the development of migraine chronification.
Full Text of this Article in Japanese PDF (179K)
(臨床神経, 52：1012−1013, 2012)
key words：片頭痛慢性化，慢性片頭痛，下行性疼痛抑制系，TRPV1（transient receptor potential vanilloid subfamily，member 1），A型ボツリヌス毒素
（受付日：2012年5月23日）
