臨床神経学

第51回日本神経学会総会

<シンポジウム09―4>ヒト中枢神経のfunctional connectivityの新しい解析法
多次元神経イメージングによる脳内ネットワーク解析

花川 隆

国立精神・神経医療研究センター神経研究所〔〒187―8502 東京都小平市小川東町4―1―1〕
科学技術振興機構さきがけ研究

Here we propose multidimensional non-invasive imaging to understand the functional anatomy of neural circuits of the human brain. The multidimensional network imaging technique currently employs anatomical, functional and evoked connectivity imaging in various combinations. The anatomical and functional connectivity imaging can be achieved by the analysis of diffusion-weighted and functional magnetic resonance imaging (fMRI), respectively. New analysis techniques such as probabilistic diffusion tractography and tract-based statistics have refined the anatomical connectivity imaging, especially in combination with fMRI for setting up regions-of-interest. For the evoked connectivity imaging, brain stimulation technique such as transcranical magnetic stimulation (TMS) is performed during acquisition of fMRI and electrophysiology monitoring. Despite technical challenges, it is important to put information from these different modalities for network imaging together for fair understanding of human brain functions.
Full Text of this Article in Japanese PDF (161K)

(臨床神経, 50:901−902, 2010)
key words:神経回路,神経機能イメージング,拡散強調トラクトグラフィー,神経電気生理,経頭蓋磁気刺激

(受付日:2010年5月22日)