臨床神経学

第50回日本神経学会総会

<シンポジウム1―1>脳梗塞UP TO DATE
脳梗塞における血栓形成メカニズム

北川 一夫, 佐古田 三郎

大阪大学大学院医学系研究科神経内科学〔〒565-0871 吹田市山田丘2-2〕

For thrombus formation, three important factors, blood flow, blood component and blood vessels, have been recognized as Virchow's triad. In cardiogenic embolism with atrial fibrillation, stagnation of blood in the left atrium causes fibrin-rich thrombus. Anticoagulation is the only effective drug for prevention of this type of thrombus. In atherothrombotic and lacunar infarction, injury of endothelium and arterial vessels and platelet play a crucial role of formation of platelet-rich thrombus. Antiplatelet drugs such as aspirin, clopidogrel and cilostazole are effective for prevention of arterial thrombus and stroke recurrence, but other drugs such as statin for plaque stabilization and improvement of endothelial function could be used to reduce the recurrence of ischemic stroke.
Full Text of this Article in Japanese PDF (382K)

(臨床神経, 49:798−800, 2009)
key words:抗凝固薬, 抗血小板薬, プラーク脆弱性, 炎症, スタチン

(受付日:2009年5月21日)