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  会員専用

• ホーム
• 48巻11号
• 臨床神経, 48：844−847, 2008
• 48巻11号目次

第49回日本神経学会総会

＜企画講演2＞
ジストニアの診断と治療―病態生理的アプローチ

梶　龍兒, 佐藤　健太, 佐光　亘, 後藤　恵

徳島大学神経内科〔〒770-8503　徳島市蔵本町2-50-1〕

Diagnosis of dystonia is not difficult by recognizing the pattern of clinical presentation. Dopa-responsive dystonia (DRD) and Wilson disease are important in differential diagnosis because of their specific treatment. The most common are the focal dystonias, including blepharospasm and spasmodic torticollis. Dystonia comprises mobile involuntary movements and abnormal postures, the latter is better described as hypokinetic disorder. The pathogenesis of dystonia is now being clarified, and includes abnormal neuroplasticity caused by the relative excess of dopamine in the matrix compartment of the striatum, the possible primary lesion being the striosome. In a dopa-responsive dystonia model, dopaminergic projection is more deficient to the striosome than to the matrix, which could produce imbalance between the direct versus. indirect pathway activities. The treatment options include trihexyphenidyl, minor tranquilizers, botulinum toxin injection, and deep brain stimulation.
Full Text of this Article in Japanese PDF (348K)

(臨床神経, 48：844−847, 2008)
key words：ジストニア, ストリオゾーム, マトリックス, DYT3

（受付日：2008年5月16日）